Medical Research

Researchers take aim at digestive disorder

Canadian researchers are testing a new drug for patients who suffer from a chronic digestive disorder called celiac disease, which appears to be afflicting a growing number of people. (Source: CTV Health)

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Finland Study Indicates Gluten Intolerance Due to Virus - eMaxHealth.com

... be connected in some way with the onset of gluten intolerance.” Gluten intolerance, also called celiac disease, is an autoimmune reaction in the small intestine that responds to the gluten protein found in wheat ... because their symptoms
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Endocytotic segregation of gliadin peptide 31-49 in enterocytes

Conclusions Endocytic segregation of gliadin peptide AA 31–49 seems to be a constitutive process. It explains why this peptide cannot stimulate gluten-sensitive T cells. Presentation of gliadin peptides by HLA-DR proteins via late endosomes within enterocytes might induce a tolerogenic effect and constitutes a potentially promising therapeutic approach for induction of tolerance towards gliadin. (Source: Gut)

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Atypical Celiac Disease: Could You Be Missing This Common Problem?

For every recognized case of celiac disease, 8 more remain undiagnosed. The reason for this disparity is contingent on the varying presentations of the disease. (Source: Consultant Live)

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13 New Variants Associated With Celiac Disease Risk

In a genomewide study, more than half the variants associated with celiac disease correlated with altered activity of nearby genes. Medscape Medical News (Source: Medscape Today Headlines)

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Celiac Disease Genes Identified In Immune System

A UK-led international study has identified four types of genetic disturbance in the immune system that lead to celiac disease, bringing to 40 the total number of known inherited factors that increase a person's risk of developing the disease. The researchers hope the findings will help to improve diagnostic tools and treatments for celiac disease, and it may also give new clues about related autoimmune diseases such as type 1 diabetes... (Source: Health News from Medical News Today)

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Pinpointing immune system disturbances in celiac disease

(Queen Mary, University of London) New research has identified four aspects of immune system disturbance which lead to the development of celiac disease. Nearly 40 different inherited risk factors which predispose to the disease have now been identified. These latest findings could speed the way towards improved diagnostics and treatments for the autoimmune complaint that affects 1 in 100 of the population, and lead to insights into related conditions such as type 1 diabetes. (Source: EurekAlert! - Medicine and Health)

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Clinics of coeliac disease in children in the 2000s

Objective: To describe the clinical picture of patients with coeliac disease (CD) and the change in its presentation over the past decades.Study design: Patients with CD were identified and clinical data collected from hospital records over a 6-year period (2000[ndash]2005).Results: Altogether 197 patients aged 0.6[ndash]15.9 (mean 7.2) years were identified. They were found amongst the child population served by the hospital, the mean number of children at age 0.5[ndash]16 years was 268 000 during 2000[ndash]2005. The presenting symptom amongst the youngest patients ( (Source: Acta Paediatrica)

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High-Resolution Array Comparative Genomic Hybridization in Sporadic and Celiac Disease-Related Small Bowel Adenocarcinomas.

CONCLUSIONS: Our study characterized chromosomal aberrations and amplifications involved in small bowel adenocarcinoma. At the chromosomal level, celiac disease-related and non-celiac disease-related small bowel adenocarcinomas did not differ. A defect in the mismatch repair pathways seems to be more common in celiac disease-related than in non-celiac disease-related small bowel adenocarcinomas. In contrast to colon and gastric cancers, no APC nonsense mutations were found in small bowel adenocarcinoma. However, APC promoter methylation seems to be a common event in celiac disease-related small bowel adenocarcinoma. Clin Cancer Res; 16(5); 1391-401. PMID: 20179237 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

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Back pain and sacroiliitis in long-standing adult celiac disease: a cross-sectional and follow-up study

Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00296-010-1375-8Authors Cumali Efe, Ankara Numune Research and Education Hospital Internal Medicine Department Yazgan sokak 21/12 Cebeci Ankara TurkeyTugrul Purnak, Ankara Numune Research and Education Hospital Gastroenterology Department Ankara TurkeyErsan Ozaslan, Ankara Numune Research and Education Hospital Gastroenterology Department Ankara TurkeyZeynep Ozbalkan, Ankara Numune Research and Education Hospital Rheumatology Department Ankara Turkey Journal Rheumatology InternationalOnline ISSN 1437-160XPrint ISSN 0172-8172 (Source: Rheumatology International)
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Study Finds Key Protein That Resists Gut Infection - Med India

A signaling protein that is key in orchestrating the body's overall immune response has an important localized role in fighting bacterial infection and inflammation in the intestinal tract, according to a study by UC San Diego School of Medicine ...
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Regulation of autonomic nerve activities by central pituitary adenylate cyclase-activating polypeptide.

Authors: Tanida M, Shintani N, Morita Y, Tsukiyama N, Hatanaka M, Hashimoto H, Sawai H, Baba A, Nagai K Pituitary adenylate cyclase-activating polypeptide (PACAP) is a peptidergic neurotransmitter that is expressed in high levels in nervous systems. Here, we investigated the roles of PACAP in autonomic system regulation by evaluating the changes caused in the autonomic nerve activities after injecting PACAP into the central nervous system (CNS) and examining stress-induced blood glucose changes in PACAP-deficient (PACAP-/-) mice. Renal sympathetic nerve activity (RSNA), blood pressure, and heart rate were elevated after injecting PACAP into the third cerebral ventricle (3CV). Similarly, other sympathetic nerve activities, including adrenal sympathetic nerve activity (ASNA), celiac symp...

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Gluten-Free Camp A Hit For Kids With Celiac Disease

Children with celiac disease who attended a gluten-free camp demonstrated improvement in well-being, emotional outlook, and self-perception, according to the study, "Impact of Gluten-Free Camp on Quality of Life of Children and Adolescents With Celiac Disease... (Source: GastroIntestinal News From Medical News Today)

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Dietary compliance and life style of children with coeliac disease

Conclusions: Children with CD have low compliance with the GFD. Better education about the disease, the availability of GF products, and appropriate food labelling could improve compliance and quality of life. (Source: Journal of Human Nutrition and Dietetics)

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